XL t(7;12) MNX1/ETV6

Translocation/Dual Fusion Probe

Order Number
D-5101-100-OG
Package Size
100 µl
Labels
  
Chromosomes
712

Description

XL t(7;12) MNX1/ETV6

The XL t(7;12) MNX1/ETV6 is designed as a dual fusion probe. The green labeled probes flank the breakpoint at 12p13 (ETV6), and the orange labeled probes flank the breakpoint at 7q36 (MNX1 formerly HLXB9).

Clinical Details

Several recurrent balanced translocations and inversions, and their variants, are recognized in the WHO category acute myeloid leukemia (AML) with recurrent genetic abnormalities. Furthermore, several cytogenetic abnormalities are considered sufficient to establish the WHO diagnosis of AML with myelodysplasia-related features when 20% or more blood or marrow blasts are present.

The t(7;12)(q36;p13) translocation is a recurrent chromosome abnormality that involves the ETV6 gene on chromosome 12 and has been identified in 20–30% of infant patients with AML. The detection of t(7;12) rearrangements relies on the use of fluorescence in situ hybridization (FISH) because this translocation is hardly visible by chromosome banding methods. The clinical outcome of t(7;12) patients is believed to be poor, therefore an early and accurate diagnosis is important in the clinical management and treatment.

Clinical Applications

  • Acute Myelogenous Leukemia (AML)

Images

XL t(7;12) MNX1/ETV6

XL t(7;12) hybridized to lymphocytes. One normal metaphase is shown.

Expected Patterns

Expected Pattern 1

Normal Cell:
Two green (2G) and two orange signals (2O).

Expected Pattern 2

Aberrant Cell (typical results):
One green (1G), one orange (1O), and two green-orange fusion signals (2GO).

Literature

  • Ballabio et al (2009) Leukemia 23: 1179- 1182
  • Naiel et al (2013) Cancers 5: 281-295
  • Owokaet al (2015) Hematol Leuk. 3: 1-4

Downloads

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