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XL t(7;12) MNX1/ETV6

Translocation/Dual Fusion Probe

Order Number
D-5101-100-OG
Package Size
100 µl (10 Tests)
Labels
  
Chromosomes
712
Regulatory Status
IVDD

IVDR Certification

MetaSystems Probes has already certified a large part of its portfolio, according to IVDR. For organizational reasons, we currently provide only the IVDD product.

Discover all IVDR-certified products

Product Description

XL t(7;12) MNX1/ETV6

XL t(7;12) MNX1/ETV6 consists of an orange-labeled probe hybridizing to the MNX1 gene region at 7q36 and a green-labeled probe hybridizing to the ETV6 gene region at 12p13.2.

Probe maps are created in accordance with the intended purpose of the product. Solid colored bars do not necessarily indicate that the probe fully covers the indicated genomic region. Therefore, caution is advised when interpreting results generated through off-label use. Probe map details based on UCSC Genome Browser GRCh37/hg19. Map components not to scale. Further information is available on request.

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Clinical Details

Several recurrent balanced translocations and inversions, and their variants, are recognized in the WHO category acute myeloid leukemia (AML) with recurrent genetic abnormalities. Furthermore, several cytogenetic abnormalities are considered sufficient to establish the WHO diagnosis of AML with myelodysplasia-related features if 20% or more blood or marrow blasts are present.

The t(7;12)(q36;p13) translocation is a recurrent chromosome abnormality which involves the ETV6 gene on chromosome 12 and has been identified in 20–30% of infant patients with AML. The detection of t(7;12) rearrangements relies on the use of fluorescence in situ hybridization (FISH) because this translocation is hardly visible by chromosome banding methods. The clinical outcome of t(7;12) patients is believed to be poor, therefore an early and accurate diagnosis is important in the clinical management and treatment.

Clinical Applications

  • Acute Myelogenous Leukemia (AML)
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Images

XL t(7;12) MNX1/ETV6

XL t(7;12) hybridized to lymphocytes. One normal metaphase is shown.

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Expected Patterns

Expected Pattern 1

Normal Cell:
Two green (2G) and two orange signals (2O).

Expected Pattern 2

Aberrant Cell (typical results):
One green (1G), one orange (1O), and two green-orange fusion (2GO) (adjacent green and orange) signals.

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Literature

  • Ballabio et al (2009) Leukemia 23:1179-1182
  • Naiel et al (2013) Cancers 5:281-295
  • Owokaet al (2015) Hematol Leuk 3:1-4

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News

IVDR Certification

MetaSystems Probes has received IVDR certification for our initial 26 fluorescence in situ hybridization (FISH) probes from the notified body, BSI. Achieving this milestone was not without its challenges, and we are delighted to have accomplished IVDR certification for this probe set at an early stage.

IVDR Certification

New Probes Catalog is Online!

 

MetaSystems Probes is pleased to announce the new catalog including new and innovative products and supporting information. A PDF version of the new catalog is available for download here.

New Probes Catalog is Online!